Inherited Obsession: The Role of Genetics and Serotonin in the Etiology of Obsessive-Compulsive Disorder

We still do not understand why some individuals are more likely to develop OCD than others. Research has implicated the serotonin system specifically the serotonin transporter and the 5-HT2A receptor as potential neurochemical underpinnings of OCD. Innovations in genetics have allowed research to hone in on the specific genes which code for the neurochemical dysfunction implicated in OCD. In this literature review, I gathered data in the form of research which addresses the neurochemical and genetic underpinnings of OCD in order to gain a better understanding of the etiology of the disorder. The findings presented represent my analysis of current research in the field in the hopes of drawing conclusions about the etiology of OCD. My conclusions implicate the specific genes which code for the serotonin transporter and the 5-HT2A receptor as the potential neurochemical and genetic underpinnings of OCD

Hardy type spaces on certain noncompact manifolds and applications

In this paper we consider a complete connected noncompact Riemannian manifold M with Ricci curvature bounded from below, positive injectivity radius and spectral gap b. We introduce a sequence X^1(M), X^2(M), ... of new Hardy spaces on M, the sequence Y^1(M/, Y^2(M), ... of their dual spaces, and show that these spaces may be used to obtain endpoint estimates for purely imaginary powers of the Laplace-Beltrami operator and for more general spectral multipliers associated to the Laplace--Beltrami operator L on M. Under the additional condition that the volume of the geodesic balls of radius r is controlled by C r^a e^{2\sqrt{b} r} for some real number a and for all large r, we prove also an endpoint result for first order Riesz transforms D L^{-1/2}. In particular, these results apply to Riemannian symmetric spaces of the noncompact type.Comment: 27 pages, v2: the first version has been revised and rearranged, with additions, in two papers, of which this new version is the first. The second paper is posted as arXiv:1002.1161v

Dietary Patterns at the Individual Level through a Nutritional and Environmental Approach: The Case Study of a School Canteen

The public catering sector has important responsibilities in seeking a change toward more sustainable choices for many aspects related to the environmental impacts of their services. The environmental impact of production processes can be studied through life cycle assessment (LCA), which allows a greater awareness of choices and has rarely been applied to catering. In this work, we studied the impacts of two dishes (braised meat and cauliflower meatballs) in a school canteen, their impacts were studied using the daily energy requirement (expressed in kcal) as a functional unit. Global warming potential (GWP) and nonrenewable energy (NRE) were calculated starting from the supply of raw materials up to distribution. Electricity and the act of cooking the meatballs accounted for more than 60% of the measured impact in terms of GWP, whereas, less markedly, they dominated in terms of nonrenewable energy used. In the case of braised meat, the total impact was, however, attributable to the life cycle of the meat (between 60% and 76%) and the consumption of electricity (between 19% and 27%), whereas for all other factors, the contribution was never particularly high. Additionally, a discussion on the correct functional unit to be used proposed the environmental impact of different recipes as an additional criterion for nutritionists during the composition of the menu. An integrated system appears important for changing policies and behaviors and the application of LCA can be a tool capable of contributing to the construction of a holistic instrument of sustainability

Unlocking Plum Genetic Potential: Where Are We At?

Plums are a large group of closely related stone fruit species and hybrids of worldwide economic importance and diffusion. This review deals with the main aspects concerning plum agrobiodiversity and its relationship with current and potential contributions offered by breeding in enhancing plum varieties. The most recent breeding achievements are revised according to updated information proceeding from relevant scientific reports and official inventories of plum genetic resources. A special emphasis has been given to the potential sources of genetic traits of interest for breeding programs as well as to the need for efficient and coordinated efforts aimed at efficaciously preserving the rich and underexploited extant plum agrobiodiversity. The specific objective of this review was to: (i) analyze and possibly evaluate the degree of biodiversity existing in the cultivated plum germplasm, (ii) examine the set of traits of prominent agronomic and pomological interest currently targeted by the breeders, and (iii) determine how and to what extent this germplasm was appropriately exploited in breeding programs or could represent concrete prospects for the future